Butler County is located in South-Central Kentucky. The City of Morgantown, the county seat, is located centrally in Butler County. Major regional connection to Butler County is provided by the William H. Natcher Parkway, running generally north-south through the center of the county. This parkway provides Butler County, and Morgantown residents, direct access to Owensboro and Bowling Green.
The William H. Natcher Parkway provides Butler County access I-65 to the east and access to the Western Kentucky Parkway to the north. KY-79 provides access to Russellville, south of Butler County. The Wendell H. Ford Western Kentucky Parkway passes through the northern part of Butler County and connects to the William H. Natcher Parkway, providing greater east-west access for Butler County.